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Prilosec ® OTC (Over-the-Counter)

Contents of this Article

  • Who Should Take Prilosec OTC?
  • Before You Use Prilosec OTC
  • Directions For Prilosec OTC
  • Tips For Managing Heartburn

Prilosec OTC

Omeprazole - chemical name - Pronunciation - o-MEP-ra-zole
Prilosec - brand name

The Food and Drug Administration (FDA) has approved the 20 mg (milligram) dosage of Prilosec as an over-the-counter medication. Milligram is one thousandth (1/1,000) of a gram.

Prilosec, a proton pump inhibitor, is currently available in dosages of 10 mg, 20 mg and 40 mg. Prilosec in the 10 mg and 40 mg size are prescriptions only.

Proton Pump Inhibitors (PPIs) are used for two reasons - chronic (lasting a long time) heartburn and gastroesophageal reflux disease (GERD), which is a more severe form of heartburn.

Proton Pump Inhibitors (PPIs) are:

  • Nexium - Esomeprazole
  • Prilosec - Omeprazole
  • Protonix - Pantoprazole
  • Prevacid - Lansoprazole
  • Aciphex - Rabeprazole

How Prilosec OTC is Sold

Prilosec OTC is available in 14 tablet, 28 tablet and 42 tablet sizes. These sizes contain one, two, and three 14 day courses of treatment, respectively. Do not use for more than 14 days in a row unless directed by your doctor. For the 28 count (two 14 day courses) and the 42 count (three 14 day courses), you may repeat a 14 day course every 4 months.

Gastroesophageal Reflux Disease (GERD)

Gastroesophageal Reflux Disease (GERD), pronounced - GAH-stroh-eh-SAW-fuh-JEE-ul REE-fluks duh-zeez, is the flow of the stomach's contents back up into the esophagus. Happens when the muscle between the esophagus and the stomach (the lower esophageal sphincter) is weak or relaxes when it shouldn't. May cause esophagitis. Also called esophageal reflux or reflux esophagitis. More about GERD


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The information discussed above is a general overview and does not include all the facts, or include everything there is to know about any medicine and/or products mentioned. Do not use any medicine and/or products without first talking to your doctor. Possible side effects of medications, other than those listed, may occur. Other brand names or generic forms of this medicine may also be available. If you have questions or concerns, or want more information, your doctor or pharmacist has the complete prescribing information about this medicine and possible drug interactions.